Activation of Microbial Silent Gene Clusters: Genomics Driven Drug Discovery Approaches
نویسنده
چکیده
Microorganisms have provided mankind with a plethora of small molecule natural products ranging from industrial enzymes to therapeutic agents. Analyses of microbial genome sequences have revealed the presence of numerous ‘silent’ or ‘cryptic’ biosynthetic gene clusters (BGCs). Activation of these cryptic biosynthetic pathways can pave way to the discovery of novel bioactive secondary metabolites (SMs). This article summarizes various approaches employed to unlock the hidden biosynthetic potential of microbes and methods developed to study their silent gene products. Activation of Microbial Silent Gene Clusters: Genomics Driven Drug Discovery Approaches Jinu Mathew Valayil*
منابع مشابه
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متن کاملSummaries Petersen/Amstutz (eds): Natural Compounds as Drugs II Summary
The ongoing exponential growth of DNA sequence data will lead to the discovery of many natural-product biosynthesis pathways by genome mining for which no actual product has been characterised. In many cases, these clusters remain silent under laboratory conditions. New technologies based on genetic engineering are available to induce silent genes. Heterologous expression of a silent gene clust...
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تاریخ انتشار 2016